permissions error

I've seen posts about this error message, here's mine.  I have no idea how to fix this, any suggestions would be appreciated.  Windows 10:

bn.BUILD_KEY: Dropbox
bn.VERSION: 142.4.4197
bn.constants.WINDOWS_SHELL_EXT_VERSION: 52
bn.is_frozen: True
machine_id: 91df7d93-0bea-417a-80e7-b7cbd0b2be20
pid: 11324
cwd: 'C:\\Program Files (x86)\\Dropbox\\Client'
real_path='C:\\Program Files (x86)\\Dropbox\\Client'
mode=0o40777 uid=0 gid=0
parent mode=0o40777 uid=0 gid=0
HOME: None
appdata: 'C:\\Users\\sklar\\AppData\\Local\\Dropbox\\instance1'
real_path='C:\\Users\\sklar\\AppData\\Local\\Dropbox\\instance1'
mode=0o40777 uid=0 gid=0
parent mode=0o40777 uid=0 gid=0
dropbox_path: 'C:\\Users\\sklar\\Dropbox'
real_path='C:\\Users\\sklar\\Dropbox'
mode=0o40777 uid=0 gid=0
parent mode=0o40777 uid=0 gid=0
sys_executable: 'C:\\Program Files (x86)\\Dropbox\\Client\\Dropbox.exe'
real_path='C:\\Program Files (x86)\\Dropbox\\Client\\Dropbox.exe'
mode=0o100777 uid=0 gid=0
parent mode=0o40777 uid=0 gid=0
trace.__file__: 'C:\\Program Files (x86)\\Dropbox\\Client\\142.4.4197\\python-packages.zip\\dropbox\\client\\ui\\common\\boot_error.pyc'
real_path='C:\\Program Files (x86)\\Dropbox\\Client\\142.4.4197\\python-packages.zip\\dropbox\\client\\ui\\common\\boot_error.pyc'
not found
parent not found
TMP: C:\Users\sklar\AppData\Local\Temp
TEMP: C:\Users\sklar\AppData\Local\Temp
tempdir: 'C:\\Users\\sklar\\AppData\\Local\\Temp'
real_path='C:\\Users\\sklar\\AppData\\Local\\Temp'
mode=0o40777 uid=0 gid=0
parent mode=0o40777 uid=0 gid=0
Traceback (most recent call last):
File "dropbox\client\main.pyc", line 831, in wrapper
File "dropbox\client\main.pyc", line 6608, in finish_dropbox_boot
File "dropbox\client\message_queue.pyc", line 313, in _wrapped
File "dropbox\client\main.pyc", line 6156, in _init_components_for_account
File "dropbox\client\main.pyc", line 6080, in create_sync_engine
File "dropbox\sync_engine_boundary\factory.pyc", line 218, in make_sync_engine
File "dropbox\sync_engine\nucleus\classic_client\sync_engine.pyc", line 262, in __init__
File "dropbox\sync_engine\nucleus\classic_client\modern_client\modern_client.pyc", line 251, in __init__
File "dropbox\sync_engine\nucleus\classic_client\modern_client\base.pyc", line 202, in __init__
File "dropbox\sync_engine\nucleus\classic_client\thin_adapter\in_proc.pyc", line 216, in __init__
File "dropbox\sync_engine\nucleus\classic_client\thin_adapter\in_proc.pyc", line 528, in _init_new_engine_locked
File "dropbox\sync_engine\nucleus\thin_client\client.pyc", line 134, in __init__
File "desktop\extensions\nucleus\nucleus_python.pyx", line 76, in nucleus_python.NucleusSyncEngine.__cinit__
nucleus_python.SyncEngineError: "Initializing engine |>> Initializing filesystem |>> Attempting to initialize dbx cache directory |>> NtSetBasicInformation syscall: new handle |>> ACCESS_DENIED |>> Permission denied"